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The Food and Drug Administration, FDA, has approved the drug Vivitrol for the treatment of opioid dependence as outlined by a news release by them on 10-12-2010.

Using two separate drugs to shed weight can be very effective you can find combinations before the FDA now awaiting approval. When dealing with weight-loss and the people who go through it you ought to err along the side of caution and allow the FDA do its job and demand some investigation be done in order that the public recognizes the side effects and risks of the medications before we bring them. Keep in mind that drug companies will be in business to earn money and that they would say everything to keep people on his or her medications.

Researchers found out that participants taking this drug for any year, dropped a few pounds within 4 weeks and have kept the extra weight off through the entire 56 weeks from the study. Contrave is a combination from the drugs naltrexone and bupropion, which seems to reflect a brand new trend of weight-loss drugs that are made up of multiple active ingredient, which might make them more effective and safer.

Combo-pilling will be the newest fad or better yet the newest in the future under scrutiny and therefore it is just more publicly known although in the past, comb-pilling for weight loss has been around since the eighties. The biggest reason that utilizing a combination of pills is becoming popular could be the fact that at the time of right now there aren't long term prescription slimming capsules that have been authorized by the FDA aside from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications however some of the combinations have been rejected or have yet to be approved by the FDA.

Seizures certainly are a side effect with Contrave and really should not be taken in people with seizure disorders. The drug could also raise hypertension and heartrate, and really should not be used in individuals with a history of cardiac event or stroke in the last six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with the drug.

The FDA also warned that Contrave can raise blood pressure levels and heart rate and must 't be used in patients with uncontrolled high blood pressure level, as well as by a person with heart-related and cerebrovascular (blood vessel dysfunction impacting mental performance) disease. Patients which has a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes which has a boxed warning to alert medical researchers and patients on the increased chance of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for smoking cessation.

Suboxone consists of two drugs; buprenorphine and naloxone. The naloxone is irrelevant if your addict uses the medication properly, but if your tablet is dissolved in water and injected the naloxone will result in instant withdrawal. When suboxone is employed correctly, the naloxone is destroyed within the liver after that uptake in the intestines and possesses no therapeutic effect. Buprenorphine may be the active substance; it can be absorbed within the tongue (and through the mouth) but destroyed from the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I used this formulation once the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I also have treated addicts who have had gastric bypass, where the first part of the intestine is bypassed and the stomach contents empty in a more distal part of the small intestine. In such cases the naloxone escapes ?first pass metabolism', the method with normal anatomy the location where the drug is taken up from the duodenum and transferred straight away to the liver by the portal vein, where it's quickly and completely destroyed. After gastric bypass naloxone can be taken on by areas of the intestine that are not served with the portal system, causing blood numbers of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.